Missing links between Central Obesity, Oxidative stress & Glycemic levels in Diabetes.

Dr. Sandhya Pillai Nair; Dr.N.C.Shah

Volume : IX, Issue : II, February - 2020

Missing links between Central Obesity, Oxidative stress & Glycemic levels in Diabetes.

Dr. Sandhya Pillai Nair, Dr. N. C. Shah

Abstract :

Obesity have been to be in epidemic proportion in the past few years. The doubling of the incidence of diabetes has also been observed. Hence this study was carried out to establish a link between obesity and diabetes. It can be concluded that increased abdominal fat leads to insulin resistance and metabolic abnormalities. The levels of MDA and antioxidants like GSH, SOD during early phase of the disease (recently diagnosed) in diabetic individuals and compare with normal subjects. A very significant increase (p<0.0001) was observed in the antioxidants levels, MDA ,HbA 1C and BMI, WHR in the study group as compared to the ones in the control. Decreased expression of antioxidant enzymes was found to be associated with the free radical levels at the same time a negative correlation between BMI and antioxidant levels have been observed. Hence we conclude that abdominal obesity is responsible for the development of diabetes and Oxidative stress, depleted antioxidant levels help in the progression of the disease.