Mediastinal NUT–midline Carcinoma in 11– year Old Boy – A Case Report

Vesna Djurovic-Sarajlic; Melika Bukvic; Irmina Sefic-Pasic; Ajdin Smajlovic

Volume : VIII, Issue : IV, April - 2019

Mediastinal NUT–midline Carcinoma in 11– year Old Boy – A Case Report

Vesna Djurovic Sarajlic, Melika Bukvic, Irmina Sefic Pasic, Ajdin Smajlovic

Abstract :

NUT–midline carcinoma is a rare and very aggressive tumor, with fast progression and poor prognosis. It should be suspected in poorly differentiated tumors, especially if located in midline structures of the head, neck, and thorax. It is characterized by gene translocation of nuclear protein in testis (NUT) gene from chromosome 15, most frequently to omodomain containing protein 4 (BDR4) gene on chromosome 19. We present a case of mediastinal NUT–midline carcinoma in 11–year old boy.CT revealed a large mediastinal mass on the right side, with elevated serum alpha–fetoprotein (AFP), neuron–specific enolase (NSE), ferritin and lactate dehydrogenase (LDH). The patient was treated with chemotherapy, but the progression of disease was rapid, and he died within four months after the onset of disease.