Malignant adenomyoepithelioma of breast cytologically masquerading as adenoid cystic carcinoma: Immunohistochemistry with review of literature

Devi Subbarayan; Nita Khurana; Shyama Jain

Volume : IV, Issue : VI, June - 2015

Malignant adenomyoepithelioma of breast cytologically masquerading as adenoid cystic carcinoma: Immunohistochemistry with review of literature

Devi Subbarayan, Nita Khurana, Shyama Jain

Abstract :

Background: Adenomyoepithelioma (AME) east is a rare epithelial – myoepithelial tumor. Rarely undergoes malignant change. We report a rare case of malignant adenomyoepithelioma (MAME) cytologically masquerading as adenoid cystic carcinoma (ACC) with literature review. Case report: We here report a case of 50 year old woman with malignant adenomyoepithelioma, whose cytomorphological features were indicative of ACC. Histologically the tumor showed biphasic proliferation of epithelial and myoepithelial cells with focal areas of ACC like pattern. Malignancy was evidenced by infiltration into the surrounding tissue with focal area of necrosis. Immunohistochemistry (IHC) confirmed the diagnosis. Conclusion: MAME is a rare neoplasm of east shows spectrum of histological pattern due to which it causes diagnostic confusion. The cytological diagnosis of this neoplasm can be challenging. The cytopathologist should aware of the variable morphological pattern of MAME