Volume : V, Issue : V, May - 2016

Labetalol versus methyldopa in the management of severe pregnancyinduced hypertension

Archana Bharti, Ajay Chhikara

Abstract :

 Objective: To assess the efficacy and safety of labetalol compared with methyldopa in the management of severe pregnancy–induced hypertension (PIH). Methods: A prospective hospital based study was conducted in the Department of Obstetrics & Gynecology, M.M.Medical College & Hospital, MMU, Kumarhatti, Solan from Feburary 2015 to January 2016. Seventy eight patients with severe PIH were allocated to receive either methyldopa (group A) or labetalol (group B). Administration of drugs with respect to Age, Gravid Status, Gestational Age, Blood Pressure Control, Time taken to Control Blood Pressure, Drug dosage, Additional Treatment, Side Effects, Perinatal safety and APGAR scores were studied. The statistical level of significance was taken at P<0.05. Results: Group A and Group B were comparable with respect to age, gravidity, gestational age and pretreatment blood pressure. Both systolic and diastolic blood pressures in labetalol group were significantly lower compared to methyldopa group at 2 hrs (‘p’ < 0.01 & < 0.001), 4 hrs. (‘p” < 0.001 & < 0.001) and 6 hrs (P < 0.05 & P < 0.01) after treatment. Labetalol was more effective, faster anti–hypertensive action and lesser side effects when compared to methyldopa. Perinatal outcome with labetalol is comparable to methyldopa. Conclusions: Present study showed that labetalol is more advantageous than methyldopa in terms of better and quicker control of blood pressure. Labetalol has comparatively less maternal side–effects with good prenatal outcome. The limiting factor in the use of labetalol is its higher cost.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Archana Bharti, Ajay Chhikara Labetalol versus methyldopa in the management of severe pregnancyinduced hypertension International Journal of Scientific Research, Vol : 5, Issue : 5 MAY 2016


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