INDUCIBLE CLINDAMYCIN RESISTANCE IN METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES IN TERTIARY CARE HOSPITAL IN SOUTHERN RAJASTHAN.

Dr. Deepika Atray; Dr. Anshu Sharma

Volume : IX, Issue : VIII, August - 2020

INDUCIBLE CLINDAMYCIN RESISTANCE IN METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES IN TERTIARY CARE HOSPITAL IN SOUTHERN RAJASTHAN.

Dr. Deepika Atray, Dr. Anshu Sharma

Abstract :

Background : Increase in the prevelance of β lactum resistance in staphylococcal infection has led to renewed interest in use of macrolide lincosamide–streptogramin B antibiotics for treatment. The routine testing for clindamycin susceptibility fails to detect inducible clindamycin resistance due to erm genes resulting in treatment failure, thus detection by a D test is necessary. Aim: Assessing the inducible clindamycin resistance using D test in clinical isolates of Staphylococcus aureus Methodology: A total of 100 staphylococcus aureus isolates were tested for routine antibiotic susceptibility by Kirby bauer method and inducible clindamycin resistance using D test. Result: Out of 100 samples, inducible resistance to clindamycin was seen in 30% isolates and constitutive resistance in 14% isolates. Out of these, inducible and constitutive resistance is higher in MRSA (39% and 30%) as compared to MSSA (22% and 0%) Conclusion: Clindamycin being a reserve drug in staphylococcal skin and soft tissue infections should be tested for inducible resistance to avoid treatment failure.