Volume : VII, Issue : IV, April - 2018
Increased resistance to anti-fungal agents by dermatophytes isolated from Sikkim, a Himalayan state of India
Dr. Rekha Sharma, Dr. Luna Adhikari, Dr. R. L. Sharma
Abstract :
Background : Dermatophytic infections and its changing pattern among people of Sikkim over the past few years and the increasing treatment failure with various antifungal agents has ought a need to start study on antifungal susceptibility testing of dermatophytes isolated from this part of the country.
Aims and objectives: To perform antifungal susceptibility testing of the isolated dermatophytes and to determine the minimum inhibitory concentration (MICs) of antifungal agents.
Materials and methods: The study was carried out from May 2016 to October 2016. A total of 60 dermatophytes isolated from the clinical specimens were tested for antifungal susceptibility.
Results: For the isolated dermatophytes, griseofulvin had the lowest MIC, followed by itraconazole and terbinafine. All the isolates showed very high MIC against fluconazole.
Conclusion: The present study highlights the drug sensitivity pattern of dermatophytes in this part of the country. Dermatophytosis is caused by multiple species, which cannot be pin point on the clinical ground and different species show different drug susceptibility pattern, which thereby suggest multidrug therapy could be a better option for the management of a case.
Keywords :
Antifungal agents Antifungal susceptibility test Dermatophytes Minimum inhibitory concentration Sikkim.
Article:
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DOI : 10.36106/ijsr
Cite This Article:
Dr. Rekha Sharma, Dr. Luna Adhikari, Dr.R. L. Sharma, Increased resistance to anti–fungal agents by dermatophytes isolated from Sikkim, a Himalayan state of India, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-4 | April-2018
Number of Downloads : 544
References :
Dr. Rekha Sharma, Dr. Luna Adhikari, Dr.R. L. Sharma, Increased resistance to anti–fungal agents by dermatophytes isolated from Sikkim, a Himalayan state of India, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-4 | April-2018
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