Volume : IV, Issue : IV, April - 2015
Impaired Increase of Plasma Abscisic Acid in Response to Oral Glucose Load in Type 2 Diabetes and in Gestational Diabetes
Ravi Yadav, Pranay Gandhi, Lokesh Kc
Abstract :
The plant hormone abscisic acid (ABA) is present and active in humans, regulating glucose homeostasis. In normal glucose tolerant (NGT) human subjects, plasma ABA (ABAp) increases 5-fold after an oral glucose load. The aim
of this study was to assess the effect of an oral glucose load on ABAp in type 2 diabetes (T2D) subjects. The increase of ABAp in response to
glucose was found to be aogated in T2D patients compared to NGT controls. A similar result was observed in the women with GDM compared to pregnant NGT controls; 8-12 weeks after childbirth, however, fasting ABAp and ABAp response to glucose were restored to normal
in the GDM subjects, along with glucose tolerance. These results indicate an impaired hyperglycemia-induced ABAp increase in T2D and in
GDM and suggest a beneficial effect of elevated ABAp on glycemic control.
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DOI : 10.36106/ijsr
Cite This Article:
Ravi Yadav, Pranay Gandhi, Lokesh KC Impaired Increase of Plasma Abscisic Acid in Response to Oral Glucose Load in Type 2 Diabetes and in Gestational Diabetes International Journal of Scientific Research, Vol : 4, Issue : 4 April 2015
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Ravi Yadav, Pranay Gandhi, Lokesh KC Impaired Increase of Plasma Abscisic Acid in Response to Oral Glucose Load in Type 2 Diabetes and in Gestational Diabetes International Journal of Scientific Research, Vol : 4, Issue : 4 April 2015
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