Hyperlipidemic and Oxidative Stress Effects of Sodium Fluoride and The Ameliorative Role of Selenium and Curcumin in Male Mice

Mohammad S. ALHarbi

Volume : III, Issue : V, May - 2014

Hyperlipidemic and Oxidative Stress Effects of Sodium Fluoride and The Ameliorative Role of Selenium and Curcumin in Male Mice

Mohammad S. Alharbi

Abstract :

was to investigate the effect of sodium fluoride on lipid profile and antioxidant enzymes and the possible protective effects of selenium and Curcumin extract against the toxicity and oxidative stress of sodium fluoride (NaF) that adversely affects antioxidant defense system and lipid profile. Mature male mice (weighing 35–45 g and each group of ten animals) were given sodium fluoride (10.3 mg/Kg bw) and/or Selenium (0.5 mg/Kg) + Curcumin extract (60 mg/Kg) daily intraperitoneally (I.P) for 4 weeks. In the present study, Sodium Fluoride exposure resulted in an increase in the Triglycerides, Cholesterol, LDL and v–LDL levels with respect to the control and significant decrease in HDL–c level. As a result, Sodium fluoride induced oxidative stress by decreasing levels of SOD, CAT, GPX, GST and increased MDA which are ameliorated by Curcumin extract and/or selenium to great extent