Geographical Distribution and Resistance pattern of Multidrug Resistant Pulmonary Tuberculosis Patients in Western Rajasthan

Dr C.R Choudhary; Dr Rajendra Kumar Garg

Volume : VI, Issue : III, March - 2017

Geographical Distribution and Resistance pattern of Multidrug Resistant Pulmonary Tuberculosis Patients in Western Rajasthan

Dr C. R Choudhary, Dr Rajendra Kumar Garg

Abstract :

Multidrug resistant tuberculosis (MDR–TB) is caused by Infection with Mycobacterium tuberculosis which is resistant to both isoniazid (INH) and rifampicin (RIF), with or without any other anti tubercular drug. To find out the number of MDR–TB diagnosed cases who were successfully initiated the treatment in MDR TB Centre of western Rajasthan also, to determine the geographical distribution of MDR TB in western Rajasthan and to facilitate early diagnosis and treatment. This five year observational, retrospective, hospital base, study was carried out in tertiary center of western Rajasthan, Kamla Nehru chest hospital, Dr. S.N. medical college Jodhpur Rajasthan, India. During the period of March 2012 to December 2016, 1225 cases of multidrug resistant tuberculosis, from 6 districts of western Rajasthan around Jodhpur were admitted and successful initiation of category 4. These patients were subjected to drug sensitivity test by a molecular diagnostic method, Using Genotype MTBDR plus kit. Out of 1225 cases of MDR TB, majority of 426/1225 cases were from Jodhpur district, 22.5% were from Pali district, 12.97% from Jalore, 11.26% from Barmer district and 5.63% from Jaisalmer district. Among these 1225 cases, Drug resistance confirmed by LPA in 864(70.5%) and gene Xpert base in 361(29.5%).207/1225 cases were rifampicin mono resistance and 657/1225(53.6%) were both isoniazid and rifampicin resistant based on LPA. Male female ratio was 3:1. The Geographical distribution of Multi drug resistant pulmonary tuberculosis in western Rajasthan is unequal as 1/3rd cases of total from Jodhpur district only. It needs early diagnosis by molecular diagnostic method and prompt treatment in other part of western Rajasthan to reduce the spread of MDR TB cases.