Genetic Variation in B–cell lymphoma 2–Associated X (BAX) Gene Confers Susceptibility to Carcinoma of Urinary Bladder

Saranjeet Kaur

Volume : III, Issue : IX, September - 2014

Genetic Variation in B–cell lymphoma 2–Associated X (BAX) Gene Confers Susceptibility to Carcinoma of Urinary Bladder

Saranjeet Kaur

Abstract :

The aim of the study was to investigate genetic polymorphism in apoptotic gene, BAX (B–cell lymphoma 2–associated X), and the risk of bladder cancer through a hospital–based case–control study. This retrospective analysis consisted of 270 cases of bladder cancer and 252 controls. The AA genotype of BAX 248 G/A polymorphism showed a 2.20–fold risk towards bladder cancer (OR = 2.20, 95% CI = 1.16–4.21) when compared to GG as the referent genotype, hence, proving the additive model. The BAX AA genotype showed a 2.56–fold increased risk (OR = 2.56, 95% CI = 1.23–5.39) of bladder cancer in males and a significantly increased risk towards bladder cancer in inhabitants of urban area (OR = 3.25, 95% CI = 1.19–9.16). Among alcoholics, both BAX AA (OR = 1.66, 95% CI = 1.27–2.17) and BAX GA + AA (OR = 2.01, 95% CI = 1.09–3.73) genotypes showed an increased risk towards bladder cancer, respectively. The BAX AA genotype also showed an increased risk towards bladder cancer among non–vegetarians (OR = 2.68, 95% CI = 0.98–7.60). Among cases having superficial stages, only the BAX AA genotype (OR = 2.19, 95% CI = 1.11–4.32) showed a significantly increased risk towards bladder cancer. The BAX AA genotype also showed a significantly increased risk (OR = 2.69, 95% CI = 1.32–5.51) towards the G2 carcinoma.