Evaluation of Stability Constants of  Gabapentine with Copper (II), Cobalt (II)  And Nickel (II)

T. Suresh; Nabiya Sultana Mayana; Hiremath Suresha Babu

Volume : II, Issue : V, May - 2013

Evaluation of Stability Constants of Gabapentine with Copper (II), Cobalt (II) And Nickel (II)

T. Suresh, Nabiya Sultana Mayana, Hiremath Suresha Babu

Abstract :

Potentiometric studies have been carried out on complexes of gabapentine (chemically 2–[1–(aminomethyl) cyclohexyl] ethanoic acid) with Cu(II), Co(II) and Ni(II). Calvin–Bjerrum pH–titration technique as used by Irving and Rossotti has been applied to determine stability constants in mixed solvents at 25 � 1oC. The present study reports the protonation constants of this ligand and stability constants of its metal complexes in aqueous, ethanol–water (25% and 50%, v/v) and dioxane–water (25% and 50%, v/v) mixtures. Metal–ligand stability constants fall in the order of Cu (II)>Co (II)>Ni (II) which in agreement with those reported by Irving stability order.