Evaluation of anti–inflammatory activity of aqueous extract of Cassia fistula fruit pulp on acute inflammation on albino rats

DR. MITALI DAS; DR. NILOTPAL BARUA

Volume : VI, Issue : VII, July - 2017

Evaluation of anti–inflammatory activity of aqueous extract of Cassia fistula fruit pulp on acute inflammation on albino rats

Dr. Mitali Das, Dr. Nilotpal Barua

Abstract :

The aim of the study was to evaluate the anti–inflammatory activity of aqueous extract of Cassia fistula fruit pulp against carrageenan induced acute inflammation in albino rats. Cassia fistula fruits were collected, washed, peeled off and after separating seeds the pulp was boiled with distilled for 30 mins, kept for 3 days and then filtered, concentrated. Oral toxicity test was done according to OECD guidelines. Anti–inflammatory activity was evaluated by carrageenan induced rat paw oedema method. Albino rats of either sex weighing 100–200gms were divided into 5 groups with 6 animals in each group. Group A received normal saline 10 ml/kg. Test groups B, C, D received aqueous extracts of Cassia fistula fruit pulp at the dose of 50,100, 200 mg/kg body weight respectively. Group E received Aspirin (100mg/kg). Aqueous extracts of Cassia fistula fruit pulp showed significant (p< 0.01) anti–inflammatory activity when compared to the control.