EVALUATION OF ANTI-DIARRHOEAL EFFECT OF CURCUMIN

Dr Anil Kumar; Dr Vijay Kumar Roy; Dr Neetu Arora; Dr Shashi Pandey

Volume : VIII, Issue : XII, December - 2019

EVALUATION OF ANTI-DIARRHOEAL EFFECT OF CURCUMIN

Dr Anil Kumar, Dr Vijay Kumar Roy, Dr Neetu Arora, Dr Shashi Pandey

Abstract :

Turmeric has been used in traditional medicine as household remedy for various diseases including biliary diseases, cough, hepatic diseases, wound healing and diarrhea etc. Curcumin is the active salt present in turmeric. This study was carried out to provide scientific basis for the use of curcumin in diarrhea and to compare it with standard medicine i.e. Loperamide. The albino rats were divided into five groups of six animals in each group. Group I (control) received vehicular fluid. Group II (positive control) received standard drug for diarrhea i.e. loperamide at the dose of 2mg/kg body weight. Group III, IV and V were administered curcumin intragastrically by the naso–gastric tube, in the dose of 500mg/kg, 750mg/kg and 1 gm/kg body weight respectively, suspended in normal saline. After one hour of above treatment, 1 ml of castor oil was given intragastrically to all the overnight–fasted animals to induce diarrhea. Each animal was housed separately and observed for time of onset and number of diarrheal episode for 4 hours. The data was analyzed by using SPSS 11. Remarkable anti–diarrheal effect of curcumin against castor oil induced diarrhea was observed in dose dependent manner. From the present study, we can draw a conclusion that, Curcumin have significant anti–diarrheal effect. It may be used as an adjuvant for the treatment of diarrhea, and irritable bowel syndrome.