Volume : VII, Issue : IV, April - 2018
Evaluation and Correlation of Density of Tumour Associated Macrophages in Oral Squamous Cell Carcinoma with or without Lymph Node Involvement: A Retrospective Immunohistochemical Analysis
Dr. Rajshri Gurav, Dr. Jigna Pathak, Dr. Shilpa Patel, Dr. Niharika Swain, Dr. Kehkashan Azmi
Abstract :
Objective: To immunohistochemically evaluate and correlate the density of tumour associated macrophages (TAMs) in Oral Squamous Cell Carcinoma (OSCC) cases with or without lymph node involvement.
Material and Methods: This retrospective study was conducted on formalin fixed paraffin embedded tissue blocks of OSCC cases (n=30) treated with neck dissection, which were retrieved from the archives of the Department of Oral Pathology and Microbiology. OSCC cases (n=30) were classified based on pathological lymph node status as with lymph node metastasis (pN+) (n=15) and without lymph node metastasis (pN–) (n=15). Immunohistochemical analysis was carried out using immunohistochemical marker CD68 for TAM. The density of CD68+ TAMs in primary tumour (OSCC) was evaluated and correlated with pathological lymph node status.
Results: The mean density of TAMs (CD68+) was increased in pN+ OSCC cases when compared to pN– OSCC cases. Statistically this difference was significant.
Conclusion: The result obtained suggested that the mean density of TAMs (CD68+) may have a predictive value in determining the metastatic potential of OSCC.
Keywords :
CD68 Macrophages Oral squamous cell carcinoma Pathological lymph node status Tumor Associated Macrophages Tumor microenvironment.
Article:
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DOI : 10.36106/ijsr
Cite This Article:
Dr. Rajshri Gurav, Dr. Jigna Pathak, Dr. Shilpa Patel, Dr. Niharika Swain, Dr. Kehkashan Azmi, Evaluation and Correlation of Density of Tumour Associated Macrophages in Oral Squamous Cell Carcinoma with or without Lymph Node Involvement: A Retrospective Immunohistochemical Analysis, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-4 | April-2018
Number of Downloads : 385
References :
Dr. Rajshri Gurav, Dr. Jigna Pathak, Dr. Shilpa Patel, Dr. Niharika Swain, Dr. Kehkashan Azmi, Evaluation and Correlation of Density of Tumour Associated Macrophages in Oral Squamous Cell Carcinoma with or without Lymph Node Involvement: A Retrospective Immunohistochemical Analysis, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-4 | April-2018
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