Volume : II, Issue : IV, April - 2013
Efficacy of Inhaled Budesonide Along with Oral Montelukast Compared to Inhaled Budesonide Alone in Patients with Mild–to–Moderate Asthma
Arun Kumar Sharma, Ramakant Dixit, Kopal Sharma
Abstract :
Background: Inhaled corticosteroids (ICS) are widely used either alone or in combination with other classes of drugs for treatment of asthma. Now–a–days leukotriene antagonists (LTRAs) have also emerged as an important drug in asthma management. Objective: To evaluate the efficacy of inhaled Budesonide along with oral Montelukast in comparison to inhaled Budesonide alone in mild–to–moderate asthmatic patients. Study design: Single blind prospective study Main outcomes: Peak expiratory flow (PEF), Forced expiratory volume in 1st second (FEV1), Forced vital capacity (FVC), and Sputum eosinophils. Method: A single blind prospective study carried at tertiary care teaching hospital. 40 patients of onchial asthma (Group A) meeting the inclusion criteria, received inhaled Budesonide 400 µg bid, 40 other onchial asthma patients (Group B) received inhaled Budesonide 400 µg bid along with oral Montelukast 10 mg OD daily for 4–weeks. Patient parameters recorded before and after study period were PEF, FEV1, FVC, and sputum eosinophil count. Results: Both groups showed progressive improvement in several measures of asthma control compared with baseline. Mean FEV1, PEF, and FVC improved significantly (p
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DOI : 10.36106/ijsr
Cite This Article:
Arun Kumar Sharma,Ramakant Dixit,Kopal Sharma Efficacy of Inhaled Budesonide Along with Oral Montelukast Compared to Inhaled Budesonide Alone in Patients with Mild-to-Moderate Asthma International Journal of Scientific Research, Vol.II, Issue.IV April 2013
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Arun Kumar Sharma,Ramakant Dixit,Kopal Sharma Efficacy of Inhaled Budesonide Along with Oral Montelukast Compared to Inhaled Budesonide Alone in Patients with Mild-to-Moderate Asthma International Journal of Scientific Research, Vol.II, Issue.IV April 2013
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