Volume : VII, Issue : IV, April - 2018
Effect Of Tween 20 And Tween 40 Surfactants On 5-Fluorouracil Niosomes
Vikesh Shukla, Mastiholimath Vs
Abstract :
Niosomes (Non–ionic surfactant vesicles) have become promising alternatives to liposomes because they are more economic and chemically
stable. Hence, Niosomes of 5–Fluorouracil were prepared by using Tween 20 and Tween 40, by ether injection method (EIM). Niosomes of Tween
40, which proved to be the best formulation, showed a mean vesicle size of 5μm and entrapment efficiency of Tween 20 and Tween 40 were found to
be 46.40% and 39.20%. The cumulative % drug release of Tween 20 and Tween 40 were 86.41% and 92.84% respectively in 12 h. The tissue
distribution studies of Tween 40 formulation reveal that the drug loaded niosomes showed preferential drug targeting to liver followed by spleen
and lungs.
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DOI : 10.36106/ijsr
Cite This Article:
VIKESH SHUKLA, MASTIHOLIMATH VS, Effect Of Tween 20 And Tween 40 Surfactants On 5–Fluorouracil Niosomes, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-4 | April-2018
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References :
VIKESH SHUKLA, MASTIHOLIMATH VS, Effect Of Tween 20 And Tween 40 Surfactants On 5–Fluorouracil Niosomes, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-4 | April-2018
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