Effect of Thyroid hormones on Blood cell counts and Blood cell indices  in Untreated and Treated Sub clinical Hypothyroidism in Shivamogga population.

Dr.Vinit Anand; Dr.Sridevi .V

Volume : V, Issue : X, October - 2016

Effect of Thyroid hormones on Blood cell counts and Blood cell indices in Untreated and Treated Sub clinical Hypothyroidism in Shivamogga population.

Dr. Vinit Anand, Dr. Sridevi . V,

Abstract :

Background: Thyroid hormones play an important physiological role in maintaining the metabolic balance of the entire body. Erythrocyte abnormalities are commonly associated with thyroid dysfunction. Thyroid dysfunction induces different effects on blood cell counts and blood cell indices. Aims and objectives: To estimate blood cell counts and blood cell indices in newly diagnosed Subclinical hypothyroid patients and to evaluate the efficacy of the L–thyroxine treatment on the same in Shivamogga population. Materials and methods: We measured Red blood cell count (RBC), White blood cells / Total leukocyte count (TLC), Differential leukocyte count (DLC), platelet (PLT) count, blood cell indices like haemoglobin [Hb] concentration, mean corpuscular volume [MCV], mean corpuscular haemoglobin [MCH], mean corpuscular haemoglobin concentration [MCHC], hematocrit (HCT) / Packed cell Volume (PCV) and Red cell distribution width (RDW) in 100 newly diagnosed subclinical hypothyroid patients & compared it with the euthyroid controls. The same patients were revaluated after treatment with L–thyroxine at the end of three months. Statistical analysis was done using independent T test. Pearson�s correlation coefficient test was done to establish the relationships between the parameters. Results: RBC count was significantly decreased in newly diagnosed Subclinical hypothyroid patients when compared to euthyroid subjects. There was no significant difference in TLC, DLC and Platelet count. Blood cell indices like Hb, MCV, MCH, MCHC and HCT were significantly decreased and RDW was significantly increased when compared with the euthyroid controls. After three months of L–thyroxine treatment, haemoglobin, RBC count, HCT, MCV, MCH, MCHC showed significant increase and there was decrease in RDW which was statistically significant. Conclusion: Thyroid dysfunction induces varied effects on haematological parameters and early intervention with thyroid replacement therapy resulted in reversible change in the haematological parameters.