Effect of Risperidone and Clozapine on Executive Functions in First Episode Schizophrenia

Dr. Ajeet Sidana; Dr. B. S. Chavan; Dr.Sukhtej Sahni

Volume : VII, Issue : III, March - 2018

Effect of Risperidone and Clozapine on Executive Functions in First Episode Schizophrenia

Dr. Ajeet Sidana, Dr. B. S. Chavan, Dr. Sukhtej Sahni

Abstract :

Aims: To compare the effect of risperidone and cloazpine on executive functioning in treatment na�ve first episode schizophrenia. Methods: A total of 55 treatment na�ve first episode patients of schizophrenia as per ICD–10 criteria, were enrolled for the study. Baseline assessment for executive functioning was carried out with TMT– A & B. Clozapine and risperidone were used in the range of 200–600mg/ day and 4–8 mg/day respectively for 6 months. Results: There was significant improvement in executive functioning in both the groups and the results were statistically significant for clozapine on TMT–B. Conclusion: The findings of current study show that both risperidone and clozapine lead to improvement in executive functioning in first episode of schizophrenia and clozapine fared better than risperidone.