Volume : IX, Issue : VIII, August - 2020

EFFECT OF PRULIFLOXACIN ON RAISED PSA

Dr Rakesh Ranjan, Dr Ravi Ranjan, Dr Nirbhay Singh

Abstract :

Objective–to evaluate the role of prulifloxacin on raised PSA Introduction– Prostate specific antigen is a glycoprotein that is serine protease. It is secreted primarily by prostate. An increase in prostate specific antigen usually indicates a prostate disease such as BPH, prostati and prostate cancer,or it may a result of manipulation of prostate like the massge of prostate or its biopsy. There may be an increase of PSA in cases of prostate disease, but it is not a necessary finding in all the men suffering from prostate disease.2 Also, an increase in PSA is not always specific to prostate cancer. .Subclinical prostatic inflammation or physiological fluctuation in PSA levels have been observed in 20–40 % cases in various clinical trials. In our study we aim to investigate effect of prulifloxacin therapy in patients with raised PSA. Methods– study was conducted on patients with Lower urinary tract symptoms, and elevated PSA(prostate specific antigen) 4–10ng/ml.3 week of tab prulifloxacin 600mg od is given to patients and PSA was repeated after 3 weeks if PSA is still found to be raise then 12 core TRUS(transrectal ultrasound) biopsy was done. Result–In 61 patients (82.4%) PSA values decreased, while in 13 patients (17.56%) PSA values increased from the initial values. 4 patients had PSA value above 50ng/ml, whose PSA values dropped significantly, after prulifloxacin administration Conclusion– There was a significant decline in the levels of PSA after three weels of purifloxacin treatment. Patients in whom there was a decrease in PSA levels of less than 4ng/mL with more than fifty percent reduction, the biopsy can be delayed. Antibiotics treatment before undergoing prostate biopsy can significantly avoid unnecessary biopsies.

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Article: Download PDF    DOI : 10.36106/ijsr  

Cite This Article:

EFFECT OF PRULIFLOXACIN ON RAISED PSA, Dr Rakesh Ranjan, Dr Ravi Ranjan, Dr Nirbhay Singh INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-8 | August-2020

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