Effect of prophylactic intraocular pressure lowering medication (brinzolamide) on intraocular pressure after ranibizumab intravitreal injection: a comparative study.

Dr KaliShankar Das; Dr Athokpam Poireiton

Volume : IX, Issue : VIII, August - 2020

Effect of prophylactic intraocular pressure lowering medication (brinzolamide) on intraocular pressure after ranibizumab intravitreal injection: a comparative study.

Dr Kalishankar Das, Dr Athokpam Poireiton

Abstract :

Aim: To evaluate the effect of prophylactic intraocular pressure (IOP) lowering medication (inzolamide) on IOP after ranibizumab intravitreal injections (IVIs). Materials and Methods: This is prospective cohort study which included 400 eyes from 400 patients (1 eye per patient) who were treated with ranibizumab intravitreal injection. Two hundred and twenty–two (222) patients in control group had received the ranibizumab IVI, but 178 patients in case group received one drop of prophylactic intraocular inzolamide pre injection. The IOP was measured by noncontact tonometer before injection, at 10, 30, 120 min and 1 day after injection in a sitting position. Results: The mean IOP measured before injection, at 10, 30, 120 min and 1 day after injection individually among cases and control groups. Comp� two groups, the mean increase on IOP was statistically significant at 10, 30, 120 min post injection (P < 0.05). Conclusions: IVI of ranibizumab causes a considerable short term transient rise on IOP in most patients. The effect of prophylactic IOP lowering medication on IOP after IVIs can be statistically significant from 10 min to 2 h after IVIs.