Dose Dependent Effect of Olive Leaves  Extract on Inflammatory Cyclooxygenase  (COX) Levels in High Fat Diet (HFD)  Induced Diabetic Animals

K. Satya Narayana; Sravanthi Koora; G. T. Sivarajasundari; Anand Shaker

Volume : II, Issue : III, March - 2013

Dose Dependent Effect of Olive Leaves Extract on Inflammatory Cyclooxygenase (COX) Levels in High Fat Diet (HFD) Induced Diabetic Animals

K. Satya Narayana, Sravanthi Koora, G. T. Sivarajasundari, Anand Shaker

Abstract :

Background : Development of diabetes and its complications are associated with persistent inflammatory activity. It has been suggested that COX–mediated pathway involved in this inflammatory process in diabetes. There is a scarcity of the studies on anti–inflammatory effect of olive leaf extract so we have chosen the Olive leaf extract for this study. Materials and methods: Albino Wistar rats were divided into five groups. 1. Control, 2.Control + Olive Leaf extract, 3.High fat diet induced Diabetes, 4.HFD + Olive leaf extract (100mg/kg), 5.HFD + Olive leaf extract (200 mg/kg). Whole blood sample was collected after 9 weeks of experimental period and analysed. Results: Increased COX I expression in platelets & COX II expression in monocytes were observed in HFD diabetic animals when compared with control animals. However, olive leaf extract treatment to HFD induced diabetic animals restored the aforementioned parameters to normal level. Conclusion: To the best of our knowledge we have done the first research on anti–inflammatory & hypolipidemic activity of Olive leaf extract and we proved it.