Volume : II, Issue : XI, November - 2013

Dexmedetomidine as an Adjuvant in General Anaesthesia

Dr. Khyati Jethva, Dr. Rupal Shah

Abstract :

INTRODUCTION: Dexmedetomidine is an alpha2 agonist. It inhibits the noradrenergic nuclei in the locus ceruleus of ainstem. It inhibits nociception in spinal cord. It decreases sympathetic outflow, circulating levels of catecholamines and heart rate. It is a very useful drug nowadays particularly in general anaesthesia. Other benefits are: It has a sedative property, decrease requirement of other anaesthetic agents, smoothen recovery and provide postoperative analgesia. Our aim is to study the efficacy of Dexmedetomidine in GA, particularly in laproscopic surgery. METHODS: This is a prospective randomized study of 40 pts of ASA grade 1, 2, 3 scheduled for laproscopic surgery divided into 2 groups. Group–1 received GA with Dexmedetomidine and Group–2 received GA without Dexmedetomidine. Induction dose of dexemedetomidine is 1 mcg/kg and maintainance dose is 0.6 mcg/kg/hr. Ramsay score every 2 min for the first 10 min considering time of study of infusion as a time zero. RESULTS: In Group–1 Ramsay score is 5. Haemodynamic stability is better in group–1 both during laryngoscopy and intrapoeratively. It decreases requirement of Pentothal during induction and isoflurane requirement. Only few patients required analgesia during first 12 hour. CONCLUSION: Dexmedetomidine provides sedation preoperatively, provides haemodynamic stability, attenuate stress response, provides sedation throughout extubation and in recovery room.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Khyati Jethva, Dr. Rupal Shah / Dexmedetomidine as an Adjuvant in General Anaesthesia / International Journal of Scientific Research, Vol.2, Issue.11 November 2013

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