Correlation between macrophage iNOS activity and serum cholesterol level  a CVD risk factor  among Indian geriatric women

Joyeta Ghosh; Aditi Nag Chaudhuri; Debnath Chaudhuri

Volume : IV, Issue : IX, September - 2015

Correlation between macrophage iNOS activity and serum cholesterol level a CVD risk factor among Indian geriatric women

Joyeta Ghosh, Aditi Nag Chaudhuri, Debnath Chaudhuri

Abstract :

<p>Ageing is a dynamic and progressive process; during aging, the functional and structural deterioration of the arterial wall advances so slowly that it often goes unnoticed. The accumulation of oxidative damage with age may occur via an increase in the generation of oxidized substances, reduction in antioxidant capacity, reduction of repairs to oxidative damage, decrease in the generation of oxidized macromolecules or a combination of these mechanisms&quot; ,&quot;thus ageing is one important risk factors in cardiovascular diseases. Nitric oxide synthases (NOS) enzyme system is an important source of reactive substances in aging. Specially among women estrogen is particularly noteworthy for its intense and beneficial effect on endothelial function by increasing production and decreasing degradation of NO which is down regulated after menopause. Macrophages are the first inflammatory cells to invade atherosclerotic lesions, and they are the main component of atherosclerotic plaques. In present study the iNOS activity of cultured macrophages from geriatric women having hypercholesterolemia were evaluated critically with their different cardiovascular risk factors. The correlation coefficient value indicates that low iNOS activity has higher risks of having various cardiovascular disease risks (BMI(r=&ndash;0.466), WC (r=&ndash;0.468) Total Cholesterol(r=&ndash;0.392), Triglyceride(r=&ndash;0.304), LDL&ndash;C (r=&ndash;0.451),HDL&ndash;C (r=&ndash;0.519)etc).</p>