Volume : IX, Issue : V, May - 2020
COMPARISON OF BIOCHEMICAL CHANGES AND MYALGIA FOLLOWING ADMINISTRATION OF SUCCINYLCHOLINE WITH OR WITHOUT PRETREATMENT WITH ROCURONIUM IN PATIENTS UNDERGOING TYMPANOPLASTY
Dr Shikha Singh, Dr A. K Sinha, Dr. Urmila Palaria, Dr. Aditya K. Chauhan
Abstract :
Objective: To study the biochemical changes and myalgia following the administration of succinylcholine (Sch) with or without pretreatment with rocuronium in patients undergoing tympanoplasty. Method: The present prospective, double–blind, randomised clinical study was conducted after receiving clearance from the institutional ethical committee. Using a closed envelope technique, 80 American Society of Anaesthesiologists (ASA) grade I/II patients aged 20−40 years scheduled for tympanoplasty under general anaesthesia were randomly divided into two groups, Group R and Group C, with 40 patients in each group. Group R patients were administered Sch with rocuronium pretreatment, whereas Group C patients were administered Sch without rocuronium pretreatment. Venous samples were drawn for serum creatinine phosphokinase levels and serum potassium levels preoperatively, intraoperatively, and 24 h postoperatively between the two groups using the unpaired t–test. Sch–induced fasciculation and postoperative myalgia are known to be a well–recognised side effects of it’s administration. Results: The mean creatinine kinase (IU/L) level 24 h postoperatively was significantly more among subjects in Group C than among those in Group R (P = 0.001). The mean potassium level 24 h postoperatively was significantly more among subjects in Group C (5.03 ± 0.90) than among those in Group R (4.79 ± 1.05), (P = 0.045). Conclusion: Pretreatment with the nondepolarising muscle relaxant, rocuronium, prior to the administration of Sch significantly reduced the side effects of Sch
Keywords :
Article:
Download PDF
DOI : 10.36106/ijsr
Cite This Article:
COMPARISON OF BIOCHEMICAL CHANGES AND MYALGIA FOLLOWING ADMINISTRATION OF SUCCINYLCHOLINE WITH OR WITHOUT PRETREATMENT WITH ROCURONIUM IN PATIENTS UNDERGOING TYMPANOPLASTY, Dr Shikha Singh, Dr A.K Sinha, Dr. Urmila Palaria, Dr. Aditya K. Chauhan INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-5 | May-2020
Number of Downloads : 233
References :
COMPARISON OF BIOCHEMICAL CHANGES AND MYALGIA FOLLOWING ADMINISTRATION OF SUCCINYLCHOLINE WITH OR WITHOUT PRETREATMENT WITH ROCURONIUM IN PATIENTS UNDERGOING TYMPANOPLASTY, Dr Shikha Singh, Dr A.K Sinha, Dr. Urmila Palaria, Dr. Aditya K. Chauhan INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-5 | May-2020
Our Other Journals...
-
Indian Journal of
Applied Research Visit Website -
PARIPEX Indian Journal
of Research Visit Website -
Global Journal for
Research Analysis Visit Website