Volume : IX, Issue : VIII, August - 2020
Comparison between Intra-articular Platelet-Rich Plasma and Corticosteroid Injection under Ultrasound Guidance in the management of Pain and improvement of functional outcome
Debasish Deb, Yumnam Nandabir Singh, Naorem Bimol Singh, Rakesh Das, Shanavas Anoth Meethal
Abstract :
Background: Knee osteoarthritis is one of the most prevalent and disabling diseases worldwide, which decreases patients’ quality of life (QoL). However, pharmacological and non–pharmacological treatments, apart from complications, could not desirably control the disease. Objectives: The current study aimed at Compå between Intra–articular Platelet–Rich Plasma and Corticosteroid Injection under Ultrasound Guidance in the management of Pain and improvement of functional outcome in patients suffering from Knee Osteoarthritis. Methods: A randomized clinical trial was performed on 67– patients with grades II–III of knee osteoarthritis (OA) coming to RIMS PMR OPD Imphal, from April 2019 to June 2020. Patients were randomly divided into two groups: Triamcinolone (A) (n=34) and PRP (B) (n=33) by quadruple block. In the group A, 40 mg Triamcinolone and in the group B, PRP was injected intra–articularly, under ultrasound– guidance, once a month, for three consecutive months. Patients’ pain intensity was evaluated based on the Visual Analog Scale (VAS), and their outcome was determined based on the Knee injury and Osteoarthritis Outcome Score (KOOS) monthly for three consecutive months, as well as six months after the treatment. Results: There were no significant differences between the groups regarding demographic characteristics. VAS assessments indicated lower pain scores in the group B than group A; the difference between the groups was statistically significant two, three, and six months after the injections. In the group B, the mean initial VAS was 7.36 ± 0.92 compared with 7.12 ± 1.29 in the group A (P = 0.385). After six months, the scores dropped to 3.45 ± 0.86 and 4.81 ± 1.4, respectively (P = 0.0001). Examination of the KOOS parameters showed a significant association between treatment outcomes in the group P than the group T. Therefore, the test showed a significant difference between the groups regarding relief of pain, improvement of symptoms and activities of daily living (ADL) two, three, and six months after treatment. There was also a significant difference between the groups in terms of the quality of life (QoL) and doing sport activities three and six months after the treatment (P < 0.05). Based on the repeated measures analysis, a significant inter– and intra–group differences in the mean score of KOOS parameters was observed between the intervals (P = 0.0001). Conclusions: The current study results showed that three intra–articular injections of Triamcinolone and PRP could reduce pain and improve articular function in patients with grades II–III knee osteoarthritis. However, pain relief and improvement in the outcomes were more effective and more prolonged secondary to PRP injections than corticosteroid
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DOI : 10.36106/ijsr
Cite This Article:
COMPARISON BETWEEN INTRA-ARTICULAR PLATELET-RICH PLASMA AND CORTICOSTEROID INJECTION UNDER ULTRASOUND GUIDANCE IN THE MANAGEMENT OF PAIN AND IMPROVEMENT OF FUNCTIONAL OUTCOME, Debasish Deb, Yumnam Nandabir Singh, Naorem Bimol Singh, Rakesh Das, Shanavas Anoth Meethal INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-8 | August-2020
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COMPARISON BETWEEN INTRA-ARTICULAR PLATELET-RICH PLASMA AND CORTICOSTEROID INJECTION UNDER ULTRASOUND GUIDANCE IN THE MANAGEMENT OF PAIN AND IMPROVEMENT OF FUNCTIONAL OUTCOME, Debasish Deb, Yumnam Nandabir Singh, Naorem Bimol Singh, Rakesh Das, Shanavas Anoth Meethal INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-8 | August-2020
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