Volume : VIII, Issue : XI, November - 2019
COMPARATIVE STUDY OF EFFICACY AND SAFETY OF LEVETIRACETAM AND CARBAMAZEPINE AS MONOTHERAPY IN PARTIAL SEIZURES
Dr. Sharma D. S. , Dr. Shirure A. P. , Dr. Gawali U. P. , Dr. Deshkar A. T.
Abstract :
Background: Carbamazepin is the preferred drug while levetiracetam is a newer drug for partial seizures. In this study, efficacy and safety of levetiracetam and carbamazepine as monotherapy in partial epilepsy is compared. Methods: Patients were randomized in two groups. Group LEV (n=30) participants were prescribed Tab Levetiracetam, 1000–3000 mg/day/oral; and group CBZ (n=30) participants were prescribed Tab Carbamazepine, 400–1200mg/day/oral. Seizure freedom, adverse effects, quality of life was assessed at the end of 12 weeks. Results: No statistical significant difference (p >0.05) in both groups in seizure free interval (96.67% vs. 80%) and number of adverse effect (30% vs. 33.33%). Improvement in quality of life was better in group LEV (64.50%) than group CBZ (57.13%) which is statistically significant. Conclusion: Efficacy and safety of levetiracetam is comparable to carbamazepine in partial seizure while quality of life is better with levetiracetam.
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DOI : 10.36106/ijsr
Cite This Article:
COMPARATIVE STUDY OF EFFICACY AND SAFETY OF LEVETIRACETAM AND CARBAMAZEPINE AS MONOTHERAPY IN PARTIAL SEIZURES, Dr. Sharma D. S., Dr. Shirure A. P., Dr. Gawali U. P., Dr. Deshkar A. T. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-11 | November-2019
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COMPARATIVE STUDY OF EFFICACY AND SAFETY OF LEVETIRACETAM AND CARBAMAZEPINE AS MONOTHERAPY IN PARTIAL SEIZURES, Dr. Sharma D. S., Dr. Shirure A. P., Dr. Gawali U. P., Dr. Deshkar A. T. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-11 | November-2019
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