Volume : V, Issue : XI, November - 2016

Bence jones Myeloma– An analysis of 28 cases

Dr. Abdul Majeed K, Dr. Pavithran K

Abstract :

 Introduction: To evaluate the clinical features and response to treatment of light chain myeloma Back Ground : Light chain myeloma constitutes 18–20% of multiple myeloma in various series and presents with renal failure in majority of patients. Material and methods: We analysed patients with light chain myeloma admitted in our hospital during the period 9/4/04 to 9/2/09. ?ere were a total of 152 patients with multiple myeloma where immunoglobulin levels were available, 103 patients had IgG myeloma, IgA in 19 patients and 2 cases of non secretary myeloma, and twenty eight patients with light chain myeloma. Results : ?ere were 28 patients with light chain myeloma 18 males and 10 females (M: F ratio 18:10), age group varying from 35 to 90 years (average 58.2). Fifty percentages of patients had tiredness and 78.5% had bone pain at presentation. Serum creatinine was elevated in 53.5% of patients, anemia in 46% of patients and four patients had high serum calcium levels at presentation. Twenty seven patients presented at stage III Salmon Durie staging system. Sixty four percentage of was kappa chain myeloma and rests were lambda chain myeloma.Twenty three patients were treated with ?alidomide /Dexamethasone and 3 with Vincristine, Adriamycin and Dexamethasone (VAD) and two patients with Melphalan, Prednisolone and ?alidomide (MPT) as initial therapy. Of the 24 evaluable patients 7 patients had complete response (CR), 6 had partial response (PR), 2 had stable disease (SD) and 7 had progressive disease. Two patients died due to disease and four lost follow up. Conclusions: Light chain myeloma accounts for 18% of total myeloma cases in our series. More than 50% patients had renal involvement at presentation.54 % patients showed response to treatment.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Abdul Majeed K, Dr. Pavithran K, Bence jones Myeloma– An analysis of 28 cases, International Journal of Scientific Research, Volume : 5 | Issue : 11 | November 2016

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