Volume : VII, Issue : VII, July - 2018
Association between alcohol intake, obesity with liver enzyme levels
Sivakumar K, Nallathambi N, Pavithra R, Thamarai R
Abstract :
Introduction
Alcohol intake and obesityare seldom associated with increased level ofliver enzymes.Only few
studies focused the threshold of alcohol intake with elevated liver enzymes and its relationship with obesity.
Objectives
To determine the prevalence of elevated serum Alanine transaminase (ALT), Aspartate transaminase (AST) and Gamma Glutamyl Transferase (GGT) levelsin alcoholics with and without obesity and to evaluate the association between alcohol intake, Body Mass Index(BMI)and Waist circumference (WC) and their combined effect with serum ALT, AST and GGT levels.
Materials and Methods
One hundred and fifty–four males of alcoholic aged 30 years and above with and without obesity were included in study group. Serum ALT, AST and GGT levels were estimated by UV kinetic method. BMI and WC were recorded in the study group. Variables were expressed as mean ± standard deviation. Serum liver enzymes, BMI and WC were correlated using Pearson’s correlation.
Results
The mean age of study population was 41.8 ± 6.2.The prevalence of individuals (29.57%)with obese and alcohol consumption had raised AST levels (52 ± 3.4) than non–obesealcoholics (33 ± 3.2).The prevalence of increased liver enzymes in obese alcoholics was more when compared to non–obese alcoholics. AST and increased WC were highly correlated with `r` value of 0.72. AST and high BMIwere correlated with `r` value of 0.41.
Conclusion
Alcohol consumption and the obesity symbiotically raise serum ALT and AST. AST is highly correlated with WC and BMI. The impact of alcohol consumption on liver enzymes increases with measures of obesity.
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DOI : 10.36106/ijsr
Cite This Article:
Sivakumar K, Nallathambi N, Pavithra R, Thamarai R, Association between alcohol intake, obesity with liver enzyme levels, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-7 | July-2018
Number of Downloads : 144
References :
Sivakumar K, Nallathambi N, Pavithra R, Thamarai R, Association between alcohol intake, obesity with liver enzyme levels, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-7 | July-2018
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