Anti-inflammatory Effects of Cannabinoid 2 Receptor Agonist, GW405833, in a Model of Carrageenan-induced Acute Inflammation of the Rat Paw

Ali Parlar; Seyfullah Oktay Arslan

Volume : VIII, Issue : II, February - 2019

Anti-inflammatory Effects of Cannabinoid 2 Receptor Agonist, GW405833, in a Model of Carrageenan-induced Acute Inflammation of the Rat Paw

Ali Parlar, Seyfullah Oktay Arslan

Abstract :

Investigate the anti–inflammatory effects of selective CB2 receptor agonist, GW405833, in the carrageenan or capsaicin paw edema test of rats. Mix type of inflammation was induced by giving an intraplantar injection of carrageneen or capsaicin–induced paw edema– Neurogenic type of inflammation was induced by giving an intraplantar injection of capsaicin into the paw. Paw thickness was measured with electronic digital calipers, prior to and 1 or 4 h following administer of capsaicin or carrageenan respectively, which corresponds to peak edema time. Pretreatment of rats with both GW405833 and diclofenac significantly attenuated carrageenan– or capsaicin–induced paw edema compared to vehicle–treated group and carrageenan– or capsaicin–treated group. CB2 receptor antagonist, AM630, significantly reversed the effect of CB2 agonist. The GW405833 significantly inhibited plasma extravasation in carrageenan– or capsaicin–induced paw edema. Diclofenac inhibited also plasma extravasation, but has effect as more week. CB2 receptor antagonist, AM630, significantly reversed the effect of CB2 agonist.