An Observation on the Significance of Prostate Specific Antigen (PSA) In Chronic Urinary Obstruction of Prostatic Pathology

Sandeep Kumar Jaiswal; Md Mazharul Haque; Nigar Perveen; Rakhi Kumari Saw; Jayesh Kumar

Volume : IV, Issue : XI, November - 2015

An Observation on the Significance of Prostate Specific Antigen (PSA) In Chronic Urinary Obstruction of Prostatic Pathology

Sandeep Kumar Jaiswal, Md Mazharul Haque, Nigar Perveen, Rakhi Kumari Saw, Jayesh Kumar

Abstract :

Chronic urinary obstruction due to prostatic pathology (Benign prostatic hypertrophy & Carcinoma of Prostate ) is a very common clinical entity. Most clinicians utilize the measurement of serum PSA as the base line screening to differentiate between BPH &Carcinoma of Prostate in patients presenting with chronic urinary obstruction of prostatic pathology as it is a simple test to perform. In recent years, prostate specific antigen (PSA) has es¬tablished itself as the most useful marker for adenocarci¬noma of the prostate and has almost replaced the total acid phosphatase and prostatic acid phosphatase (PAP) for screening, diagnosing and monitoring the prostate car–cinoma patients. The PSA levels also rise in benign hyper¬plasia of prostate (BPH) but to a lesser extent and high values are usually diagnostic of malignant disease. The present investigation was conducted to study the relevance PSA in prostatic dis¬ease particularly in the context of hospitalized patients with retention of urine. In this study 200 cases of urinary obstruction due to prostatic pathology were studied. They were evaluated with a combination of DRE, trans abdominal ultrasound and measurement of serum PSA and results correlated with histological findings of the operated specimens. 190 patients were diagnosed with BPH and 10 with adenocarcinoma of prostate. Serum PSA had sensitivity of 90% in detecting Ca Prostate when the level of serum PSA was greater than 4ng/ml. In the range less than 4ng/ml it had a sensitivity of 60.52% in detection of BPH. In this study we infer that serum PSA is a good marker for diagnosis and differentiation between benign and malignant diseases of prostate.