An Antibiotic Susceptibility Pattern of  Various isolates of Neonatal Septicaemia – Study in tertiary care hospital, Rajkot

Dr. Ekta G; Dr. Madhulikan M; Dr. Yogesh G; Dr. Vibha; Dr. Punit

Volume : II, Issue : II, February - 2013

An Antibiotic Susceptibility Pattern of Various isolates of Neonatal Septicaemia – Study in tertiary care hospital, Rajkot

Dr. Ekta G, Dr. Madhulikan M, Dr. Yogesh G, Dr. Vibha, Dr. Punit

Abstract :

Background: Neonatal septicemia is a major cause of Neonatal morbidity & mortality in developing country more commonly due to improper aseptic condition during delivery and postnatal follow up. As in this new era due to use of oad spectrum availabity of newer and more potent antibiotics, resistant strain became a major problem in NICU. It might be possible to reduce these deaths by early diagnosis and proper management. Objectives: To know the antibiotic susceptibility pattern of various isolates. Methods: A hospital based prospective study was carried out in 100 clinically suspected cases of neonatal septicaemia in New Born Intensive Care Unit (NICU) at P.D.U Medical College & Hospital Rajkot. Results: Out of 100 neonates with clinically suspected neonatal septicemia, 62(62%) were blood culture positive. Gram negative bacteria accounted for 50(80.65%) & Gram positive bacteria accounted for 12(19.35%) of all cases. The antibiotic sensitivity of Gram negative isolates in screening test suggested 100% Extended Spectrum Beta Lactamases (ESBLs) producers. Gram Positive Bacteria like staph.aureus is 100%sensitive to linezolid, 75%sensitive to vancomycin, whereas CONS and enterococci shows were sensitive to 100% sensitive to linezolid, vancomycin, Rifampicin. Methicillin resistance was seen in 75% of Staphylococcus aureus and 66.66%of Coagulase negative staphylococcus .Gram Positive cocci were all sensitive to Vancomycin. Conclusion: Organisms isolated from neonatal septicaemia are multidrug resistant. Continued surveillance for various isolates and their susceptibility tests should be done effectively and timely to treat the patients of neonatal septicaemia This study will guide the physician to formulate antibiotic stategy which prevent the mortality & morbidity as well emergence of resistant organisms.