A Randomized, Double-Blinded,Controlled Study For Comparative Evaluation Of Intrathecal Administration Of Levobupivacaine With Fentanyl And Levobupivacaine

Geetha Ramadurai; Shobhit Singh; Neelam Singh; L.S. Mishra; Krishna Chandra Gupta

Volume : IX, Issue : IV, April - 2020

A Randomized, Double-Blinded,Controlled Study For Comparative Evaluation Of Intrathecal Administration Of Levobupivacaine With Fentanyl And Levobupivacaine

Geetha Ramadurai, Shobhit Singh, Neelam Singh, L. S. Mishra, Krishna Chandra Gupta

Abstract :

Context:Intrathecal administration of levobupivacaine with fentanyl and levobupivacaine with magnesium sulfate for postoperative analgesia.Aim:To compare the quality and duration of postoperative analgesia by addition of fentanyl or magnesium sulfate to levobupivacaine given intrathecally.Setting and design: The study was conducted as a Randomized, Double–Blinded, Controlled Study in a 1200 bedded teaching hospital.Materials and methods:60 patients undergoing lower abdominal surgery were randomly divided into two groups 30 each, group LF received 12.5 mg of 0.5% isobaric levobupivacaine with 25mcg fentanyl. Group LM received 12.5 mg of 0.5% isobaric levobupivacaine with 25mg of magnesium sulfate. Onset of sensory and motor block, duration and quality of analgesia was noted along with intraoperative hemodynamic parameters.Statistical analysis: Microsoft Excel 2010 with student �t� test (unpaired) and one way ANOVA were used for comp� the two groups.Results:The addition of fentanyl to levobupivacaine prolonged the duration of sensory block(LF 235.83�18.10 vs LM 205.17�19.14),motor block(LF 190.5�13.60 vs LM 152.47�10.63) and duration of analgesia(LF 287.5�16.12 vs LM 246.33�19.38) compared to MgSO4 with p<0.05 found statistically significant.Conclusion:Intrathecal levobupivacaine plus fentanyl prolonged the duration of sensory and motor block and provided prolonged duration of analgesia.