A NOVEL AND GREEN ROUTE FOR SYNTHESIS OF PYRAZOLINE DERIVATIVES IN AN AQUEOUS MEDIA BY USING IONIC LIQUID AT REFLUX CONDITION

Dhanmane Sushilkumar A; Prof.Shingare Muralidhar S

Volume : IV, Issue : III, March - 2015

A NOVEL AND GREEN ROUTE FOR SYNTHESIS OF PYRAZOLINE DERIVATIVES IN AN AQUEOUS MEDIA BY USING IONIC LIQUID AT REFLUX CONDITION

Dhanmane Sushilkumar A, Prof. Shingare Muralidhar S

Abstract :

A novel and green route was develop for the synthesis of 1,3,5–trisubstituted pyrazoline derivatives from phenyl hydrazine and substituted chalcones in an aqueous media by using 1–ethyl–3–methylimidazolium hydrogen sulfate ionic liquid as a catalyst at reflux condition. The reaction protocol gave 1, 3, 5–trisubstituted–2–pyrazolines in good to high yields via a one–pot addition–cyclocondensation between chalcones and arylhydrazines. The catalyst can be reused without much loss in the catalytic activity. The structures of the synthesized compounds were confirmed by their spectral data analysis.