Volume : VIII, Issue : II, February - 2019
A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND FENTANYL PREMEDICATION FOR INDIRECT ASSESSMENT OF NEUROENDOCRINE STRESS RESPONSE DURING LAPAROSCOPIC CHOLECYSTECTOMY
Dr. Paayal Chandrashekar, Dr. Roshith Thomas, Dr. Vasantha O T, Dr. Sampathila Padmanabha
Abstract :
Introduction: Hyperglycemia is a characteristic feature of the metabolic response to surgery. A prospective randomized observational study was conducted to compare the efficacy of dexmedetomidineand fentanyl in attenuating the neuroendocrine stress response by measuring serial random blood sugar level in patients undergoing laparoscopic cholecystectomy.Methodology: 40 patients of ASA physical status I or II of either sex, aged between 35–65 yrs scheduled to undergo laparoscopic cholecystectomy under general anaesthesia were randomly divided by envelope method into one of the 2 groups of 20 patients each (group D and group F). Patients allocated in group D patients (n = 20) were given IV infusion of dexmedetomidine 1μg/kg in 100 ml normal saline and Group F patients (n = 20) were given IV infusion of fentanyl 2 μg/kg in 100 ml normal saline over a 15 min period before the induction of general anaesthesia. Serial random blood sugarestimation was done perioperatively. Heart rate (HR), Oxygen saturation (SPO2), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were recorded at various time intervals.
Keywords :
Hyperglycemia neuroendocrine response hemodynamic stress response laparoscopic cholecystectomy dexmedetomidine
Article:
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DOI : 10.36106/ijsr
Cite This Article:
A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND FENTANYL PREMEDICATION FOR INDIRECT ASSESSMENT OF NEUROENDOCRINE STRESS RESPONSE DURING LAPAROSCOPIC CHOLECYSTECTOMY, Dr. Paayal Chandrashekar, Dr. Roshith Thomas, Dr. Vasantha O T, Dr. Sampathila Padmanabha INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-2 | February-2019
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A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND FENTANYL PREMEDICATION FOR INDIRECT ASSESSMENT OF NEUROENDOCRINE STRESS RESPONSE DURING LAPAROSCOPIC CHOLECYSTECTOMY, Dr. Paayal Chandrashekar, Dr. Roshith Thomas, Dr. Vasantha O T, Dr. Sampathila Padmanabha INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-2 | February-2019
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