Volume : III, Issue : II, February - 2014
Clinico–Pathological Correlation Of The Expression Of Cyclin D1 And Bcl–2 In Oral Squamous Cell Carcinomas –A Tissue Microarray Study
Dr Monica Charlotte Solomon, Dr M S Vidyasagar, Dr Donald Fernandes, Drvasudeva Gudattu
Abstract :
Oral squamous cell carcinomas (OSCC)containa heterogenous tumor cell population that are at different stages of differentiation and with different levels of proliferative potential. Hence, the behavioural pattern of individual cases is poorly predictable. Several molecules play a vital role in the step-wise process of oral carcinogenesis. A better understanding of the interaction of these molecules will help in identifying the subgroup of patients with poor outcomes. Aim and Objective To analyse the immunohistochemical expression of the cyclin D1 and bcl-2 in oral squamous cell carcinomas. To evaluate the possible association between cyclin D1 and Bcl-2 during the progression of oral squamous cell carcinomas. Settings and Design A systematic approach of tissue microarray technology and immunohistochemistry analysis for a cohort of oral squamous cell carcinoma patients. Materials and methods: Formalin Fixed Paraffin Embedded (FFPE) tissue blocks of histological proven cases of OSCC (n=119) were selected. Tissue microarray (TMA)paraffin blocks were constructed using a “handy tissue microarrayer”. 4 µm thick sections were cut from the TMA blocks and the sections were immunostained with cyclin D1 and Bcl2. A semiquantitative analysis of the immunohistochemical expression of these markers in the tumor cells was carried out.
Keywords :
Article:
Download PDF
DOI : 10.36106/ijsr
Cite This Article:
Dr Monica Charlotte Solomon, Dr M S Vidyasagar, Dr Donald Fernandes, DrVasudeva Gudattu Clinico-Pathological Correlation Of The Expression Of Cyclin D1 And Bcl-2 In Oral Squamous Cell Carcinomas -A Tissue Microarray Study International Journal of Scientific Research, Vol.III, Issue.II February 2014
Number of Downloads : 955
Dr Monica Charlotte Solomon, Dr M S Vidyasagar, Dr Donald Fernandes, DrVasudeva Gudattu Clinico-Pathological Correlation Of The Expression Of Cyclin D1 And Bcl-2 In Oral Squamous Cell Carcinomas -A Tissue Microarray Study International Journal of Scientific Research, Vol.III, Issue.II February 2014
Our Other Journals...
-
Indian Journal of
Applied Research Visit Website -
PARIPEX Indian Journal
of Research Visit Website -
Global Journal for
Research Analysis Visit Website