To Evaluate The Effect Of Addition Of Clonidine And Fentanyl To Hyperbaric Bupivacaine 0.5% Intrathecally In Patients Undergoing Lower Segment Caesarean Section.

Dr. Chhaya M. Suryawanshi; Dr. Bhavini B. Shah; Dr. Mridul Dua; Dr. Naramaneni Santhi; Dr. Anil Kumar

Volume : VI, Issue : VII, July - 2016

To Evaluate The Effect Of Addition Of Clonidine And Fentanyl To Hyperbaric Bupivacaine 0.5% Intrathecally In Patients Undergoing Lower Segment Caesarean Section.

Dr. Chhaya M. Suryawanshi, Dr. Bhavini B. Shah, Dr. Mridul Dua, Dr. Naramaneni Santhi, Dr. Anil Kumar

Abstract :

BACKGROUND: The aim was to compare clonidine and fentanyl as additives to hyperbaric bupivacaine 0.5% intrathecally in patients undergoing lower segment Caesarean section with regard to their efficacy and safety for spinal anaesthesia, and post operative analgesia. MATERIAL AND METHOD: Sixty parturients of ASA grade I and II posted for elective and emergency Caesarean section were chosen for this prospective double blind study and randomly allocated into three equal groups of twenty each. Group A received 0.5 ml of clonidine (75 μg), Group B received 0.5 ml of fentanyl (25 μg), Group C received 0.5 ml of normal saline, as an adjuvant to 2 ml hyperbaric bupivacaine 0.5 % (10 mg) intrathecally. Block characteristics such as time of onset, sensory, motor levels, duration of analgesia, need of rescue analgesia, maternal side effects and foetal outcome were evaluated. For rescue analgesia injection tramadol 100 mg was given. RESULTS: There was no statistical significance (P>0.05) for sensory and motor onset and peak sensory and peak motor effect among the groups. Time of rescue analgesia was significantly prolonged in clonidine group (677.7±179.3 min) than fentanyl group (345 ± 62.8 min) and lowest in control group (160±20.1). No significant change on baby’s APGAR score in either group. Side effects like hypotension and adycardia were observed more in clonidine group than fentanyl and control groups. CONCLUSION: Adding clonidine or fentanyl to bupivacaine prolongs the duration of spinal anaesthesia and analgesia. With clonidine, more prolonged duration of analgesia than fentanyl, without severe side effects, was observed.