To Evaluate the Anxiolytic Effect of Diltiazem in Albino Rats by Elevated�Plus Maze Model.

Dr. Dattatraya. K. Joshi; Mr. P. Durga Prasad; Dr. Bheemesh Naidu Mattam

Volume : VII, Issue : II, February - 2017

To Evaluate the Anxiolytic Effect of Diltiazem in Albino Rats by Elevated�Plus Maze Model.

Dr. Dattatraya. K. Joshi, Mr. P. Durga Prasad, Dr. Bheemesh Naidu Mattam

Abstract :

Diltiazem, a Calcium channel antagonist (CCA), is widely used in treatment of variety of cardio–vascular disorders for their actions on the Voltage Sensitive Calcium Channels (VSCC) in cardiac and smooth muscles. As some patients with ischemic heart disease (IHD) have an anxiety state apart from chest pain and diltiazem is a known CCA prescribed for IHD patients, the present study is taken up to evaluate anxiolytic action of diltiazem in albino rats in elevated plus maze model, an experimental model of anxiety. Diltiazem is evaluated for anxiolytic effect in graded doses of 5mg/kg, 10mg/kg & 20mg/kg body wt i.p. (intraperitoneal) and their effects are compared with standard drug Diazepam. The test drug diltiazem produced significant anxiolytic effect at doses of 10mg/kg & 20mg/kg body wt i.p treatment. Further, low dose combination of Diltiazem 5 mg/kg body wt + Diazepam 1 mg/kg body wt i.p. treatment showed potentiation of anxiolytic effect in elevated plus maze model.