THE UTILITY OF TOLUIDINE BLUE AS A DIAGNOSTIC ADJUNCT IN DYSPLASTIC ORAL LICHEN PLANUS

S K Padmakumar; Sivakumar R; Renu Chandran M; Alex K Varghese

Volume : VIII, Issue : VII, July - 2018

THE UTILITY OF TOLUIDINE BLUE AS A DIAGNOSTIC ADJUNCT IN DYSPLASTIC ORAL LICHEN PLANUS

S K Padmakumar, Sivakumar R, Renu Chandran M, Alex K Varghese

Abstract :

Although oral lichen planus is considered as a potentially malignant disorder, still there are controversies regarding its malignant transformation. The actual overall frequency of malignant transformation is low, varying between 0.3 and 3%. Histopathology is considered as the gold standard for the diagnosis of dysplastic OLP. Toluidine blue is a basic metachromatic stain which shows affinity for DNA and RNA. 30 patients were selected who were clinically suspicious of dysplastic OLP. Biopsy was taken to correlate the clinical and histological features. The association of biopsy findings and percentage of detection was tested statistically and was found highly significant (p >.001). Sensitivity and specificity were estimated as 90% and 100% respectively. Accuracy was found to be 92.5%.