THE EFFECT OF OXYTOCIN PLUS MISOPROSTOL VERSUS OXYTOCIN OR MISOPROSTOL ALONE IN REDUCING BLOOD LOSS AT CAESAREAN SECTION

Dr. Preeti Baghel; Dr. Anita; Dr. Manju sharma

Volume : VIII, Issue : X, October - 2018

THE EFFECT OF OXYTOCIN PLUS MISOPROSTOL VERSUS OXYTOCIN OR MISOPROSTOL ALONE IN REDUCING BLOOD LOSS AT CAESAREAN SECTION

Dr. Preeti Baghel, Dr. Anita, Dr. Manju Sharma

Abstract :

Introduction: PPH is defined as blood loss of > 500 ml after vaginal delivery or a loss > 1000 ml after caesarean delivery and > 1500 ml after caesarean hysterectomy.³Majority of maternal deaths about 50–70% occur in postpartum period of which 45% death occurs in first 24 hrs of hospital admission, 34.14% dying within 6 hrs of delivery and 22% death occurs within a hour of admission due to PPH. Three main groups of oxytocic drugs play an important role in management of atonic PPH. They are Oxytocin ,Ergot Alkaloids, Prostaglandins .

Material and Methods: This islongitudinal type of observational study is conducted in the Department of Obstetrics and Gynaecology at MCSG , S.M.S. medical college, Jaipur. 126 pregnant women were allocated to one of the three groups of 42 each by chit method. First was Oxytocin group (Group–A),Second Misoprostol group (Group–B), Third combined misoprostol–oxytocin group (group C)< style="mso–special–character:line–eak" /> < style="mso–special–character:line–eak" />

Results: There is no significant difference in blood loss in misoprostol or oxytocin alone given in patients. There was significantly low blood loss in combined use of lower doses of oxytocin and misoprostol in compared to using higher doses of oxytocin and misoprostol alone.

Conclusions: A synergistic effect of oxytocin and misoprostol allow a reduction in dose for both agent and therefore limit the side effects while improving the efficacyin reducing blood loss in caserean section.