The anti�ulcer and anti�hypothyrodism effects of Proanthocyanidin and Ranitidin in Female Rabbits with Gastric Ulceration  Induced by Indomethacin

Abrar S. Abdul –Razak; Muna H. AL–Saeed; Eman  A. AL–Masoudi

Volume : V, Issue : XI, November - 2015

The anti�ulcer and anti�hypothyrodism effects of Proanthocyanidin and Ranitidin in Female Rabbits with Gastric Ulceration Induced by Indomethacin

Abrar S. Abdul Razak, Muna H. Al Saeed, Eman A. Al Masoudi

Abstract :

 The present study aimed to evaluate the anti–ulcer activity of proanthocyanidin extracts of the grape seeds (Vitis vinifera) by using models of acute gastric lesions in rabbits induced by indomethacin. In addition to, attempt had been done to study the effect of proanthocyanidin on thyroid gland dysfunction caused by indomethacin . Thirty mature female rabbits were divided into five groups of equal number(6) as the following:: Group1:– healthy (negative control group) was administered normal saline (0.9 of Nacl) for 10 days; Group 2: was given indomethacin 75mgkg B.W. for two days(positive control group); Group 3:– was administered indomethacin 75mgkg B.W. for two days, then treated with proanthocyanidin(PA) 100mgkg B.W. for 10 days; Group 4, was given indomethacin 75mgkg for two days, then treated with proanthocyanidin(PA) 200mgkg for 10 days; Group 5, was given indomethacin 75mgkg for two days, then treated with ranitidin 50mgkg for 10 days. The results showed that proanthocyanidin(PA) and ranitidin caused significant reduction (P≤0.05) in gastric volume, ulcer area with significant increase (P≤0.05) in gastric pH, and inhibition 100% and 71.09% of gastric ulceration female rabbits treated with (proanthocyanidin in a dose of 100mg/kg & 200mg/ kg) and ranitidine respectively compared with negative control group. In addition to, it also revealed significant increase (P≤0.05) of TSH in female rabbits treated with indomethacin compared with the negative control and another groups. Indomethacin caused significant decrease (P≤0.05) in T3 and T4 compared with negative control group and another groups. It is conclude that proanthocyanidin extract of the grape seeds (Vitis vinifera) has good antiulcer activity and high effectiveness in ameliorating the hypothyroidism–induced by indomethacin.