Synthesis and Antimicrobial Studies of Some New  Substituted 4–arylidene–3–methyl–1H–pyrimido[6,1–b] quinazoline–1,10(4H)–diones

Ravi R. Vidule

Volume : III, Issue : VIII, August - 2013

Synthesis and Antimicrobial Studies of Some New Substituted 4–arylidene–3–methyl–1H–pyrimido[6,1–b] quinazoline–1,10(4H)–diones

Ravi R. Vidule

Abstract :

Synthesis of substituted 4–arylidene–3–methyl–1H–pyrimido[6,1–b]quinazoline–1,10(4H)–diones [4a–t] is attempted by the condensation of aromatic aldehydes [3a–d] with 3–methyl–1H–pyrimido[6,1–b]quinazoline1,10(4H)–diones derivatives [2a–e] in the presence of piperdine. [2a–e] were obtained by azeotropic distillation of 6–methyl uracil and deravaties of 1H–benzo[d][1,3]oxazine–2,4–diones [1a–e]. The structures of synthesized compounds are confirmed by IR and 1HNMR, 13CNMR and mass spectral studies. Further, they were screened in vitro for antibacterial activity against Escherichia coli and Salmonella typhi. Antifungal activity is evaluated against Aspergillus niger and Penicillium chrysogenum using Paper disc diffusion method. Some of the compounds were found to exhibit promising antibacterial and antifungal activities.