Study on comparison of nebulization with salbutamol alone with combination of salbutamol and ipratropium bromide in the treatment of acute exacerbation of Bronchial Asthma

Dr. Boddupalli Ramakrishna; Dr. Thirupathi Koppala; Dr.G. Snigdha

Volume : IX, Issue : VIII, August - 2019

Study on comparison of nebulization with salbutamol alone with combination of salbutamol and ipratropium bromide in the treatment of acute exacerbation of Bronchial Asthma

Dr. Boddupalli Ramakrishna, Dr. Thirupathi Koppala, Dr. G. Snigdha

Abstract :

Introduction: Asthma is a chronic inflammatory condition of the lung airways resulting in episodic airflow obstruction. This chronic inflammation heightens the airway hyper responsiveness (AHR). Asthma is defined by the history of respiratory symptoms like wheeze, shortness of eath, chest tightness and cough that vary over time and in intensity together with variable expiratory airflow limitation.1 Aims& Objectives: To compare the effectiveness of a combination of inhaled anticholinergics (ipratropium omide) and beta 2 agonists (salbutamol) compared with beta 2 agonists (salbutamol) alone for the treatment of children with acute exacerbation of asthma. Methods: This is a randomized comparative study conducted in the Department of pediatrics ASRAM Medical College during the period May 2018 to June2019. Total 66 children between the age group of 1–15 years with eligible diagnostic criteria were included in the study. Results: The percentage increase in predicted PEFR is better in Group II with a mean of 24.74 compared to Group I with a mean of 13.35. The p value is highly significant 0.001. The mean PAS at the start of the study is 10.5 in Group I and 10.7 in Group II. The mean PAS at the end of the study is 7.19 in Group I and 5.77 in Group II. The p value is 0.001 and is highly significant. The outcome is better in Group II when compared to Group I with a better decrease in PAS and better increase in percentage predicted PEFR. Conclusion: In the present study it has been proven the repeated doses of Ipratropium omide combined to Salbutamol is beneficial and it reduces the oncomotor cholinergic tone.