Studies of Acoustic Properties of Substituted Heterocyclic Drugs in Dioxane & Dioxane–Water Mixture At 290C.

Y. K. Meshram; K.N.Sonune; Rohinee R. Dharamkar

Volume : III, Issue : VII, July - 2014

Studies of Acoustic Properties of Substituted Heterocyclic Drugs in Dioxane & Dioxane–Water Mixture At 290C.

Y. K. Meshram, K. N. Sonune, Rohinee R. Dharamkar

Abstract :

The acoustical properties have been investigated from the ultrasonic velocity and density measurement of substituted heterocyclic drugs such as Acenocoumarol { 4–Hydroxy–3–[1(4–nitrophenyl)–3–oxobutyl]–2Hchromen–2–one}, Allopurinal { 1,5 dihydro–4H–pyrazolol(3,4–d)pyrimidin–4–one}, Warfarin {3(–acetonyl benzyl) –4–hydroxy coumarin} in 10% DMF at 300K. The measurement have been perform to evaluate acoustical parameters such as –Ultrasonic Velocity (Us), Density( ds), Adiabatic compressibility (βs), Intermolecular length( Lt), Partial molal compressibility ( φok(s) ), Apparent molal volume ( φv), Apparent adiabatic compressibility (φk(s)), Relative association(RA), Specific acoustic impedence (Z), partial molal volume (φov). The behavior of solutions of these compounds in Dioxane and Dioxane–water mixture.