Volume : VI, Issue : II, February - 2016
SIMULTANEOUS ESTIMATION OF A THREE COMPONENT MIXTURE OF ASPIRIN, CAFFEINE AND ORPHENADRINE CITRATE BY UV SPECTROPHOTOMETRIC METHOD OF ABSORBANCE CORRECTION FOR INTERFERENCE
Sanjay Pai Pn, Gaude Sameeksha, Anusha Palekar
Abstract :
A simple, rapid, sensitive, accurate and economical UV spectrophotometric method was developed and validated for the simultaneous estimation of aspirin, caffeine, and orphenadrine citrate by absorbance corrected for interference method using 0.1 N NaOH as solvent. The method employs measurement of aspirin at 308 nm, measurement of corrected interference at 278 nm for estimation of caffeine and at 224 nm for estimation of orphenadrine citrate. Beer’s law was obeyed in the concentration range of 3–24 µg/mL for aspirin, 1–12 µg/mL for both caffeine and orphenadrine citrate with r2 value of 0.999, 0.999, and 0.994 respectively. Accuracy was determined by recovery studies and showed percent recovery ranging from 95.76–100.33% for aspirin, 100.7–102% for caffeine and 100.66–105% for orphenadrine citrate. The mean RSD was found to be less than 2%. The developed method can be used in QC laboratory for routine analysis to ensure the identity, purity, and performance of the drug product.
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DOI : 10.36106/ijar
Cite This Article:
Sanjay Pai PN, Gaude Sameeksha, Anusha Palekar Simultaneous Estimation of A Three Component
Mixture of Aspirin, Caffeine and Orphenadrine
Citrate by Uv Spectrophotometric Method of
Absorbance Correction for Interference Indian Journal of Applied Research, Vol.6, Issue : 2 February 2016
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Sanjay Pai PN, Gaude Sameeksha, Anusha Palekar Simultaneous Estimation of A Three Component Mixture of Aspirin, Caffeine and Orphenadrine Citrate by Uv Spectrophotometric Method of Absorbance Correction for Interference Indian Journal of Applied Research, Vol.6, Issue : 2 February 2016
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