Screening of Anti–diabetic Activity of Coscinium fensestratum colebr Bark in Alloxan Induced Wistar Albino Diabetic Rats

Ganesh V; Sandeep VM; Mohamed Gani A; Sarath Babu K

Volume : VI, Issue : V, May - 2016

Screening of Anti–diabetic Activity of Coscinium fensestratum colebr Bark in Alloxan Induced Wistar Albino Diabetic Rats

Ganesh V, Sandeep Vm, Mohamed Gani A, Sarath Babu K

Abstract :

This study was conducted to evaluate the anti–diabetic activity of Coscinium fensestratum cole bark in Alloxan induced diabetic rats. 18 Wistar strain of Albino rats weighed with 200–250grams were selected for the study. The rats were divided in to three groups. G–I served as Control, G–II is standard (Glibenclamide 10 mg/kg) and G–III is test (aqueous extract of Coscinium fensestratum cole bark 500 mg/kg). This study was ethically cleared from institutional animal ethics committee. All the rats were treated with their respective drugs. Blood samples were collected at different time levels 0, 4th, 6th and 8th hour. Serum was separated and used for glucose estimation. The data was analyzed by SPSS (16.0) version. Rats treated with Alloxan showed significant increase levels of glucose at all the time periods compared to standard and test drugs. Plant extract given rats showed significant decrease in glucose levels compared to control group. Aqueous extract of Coscinium fensestratum cole bark showed significant hypoglycemic effect in Alloxan induced diabetic rats.