Volume : V, Issue : VIII, August - 2015

Role of methylxanthines in the treatment of apnea in neonates

Sankpal D M, Pradnyesh Gorad

Abstract :

<p> Apneic episodes occur frequently in premature infants and is a major contributor to the morbidity and mortality in the low birth weight infants. For such episode, tactile stimulation and positive pressure ventilation are tried first. Respiratory stimulant drugs like caffeine, methylxanthines, doxapram are also tried. Therefore this study was planned to evaluate role of different methylxanthines in the treatment of apnea. 40 neonates with neonatal apnea admitted in (NICU) were evaluated. The recording of the apnea was done with apnea monitors and observation by the nursing staff/doctors. Study group was randomised in to caffeine group or aminophylline group.Appropriate dosage regimen was followed. The blood samples were collected 24 hours after the loading dose for monitoring the drug levels. The possible adverse effects were recorded. Survival outcome was monitored with both modes of treatment. 40 infants with apneic episodes were included in the study. There were 26 males(65%) and 14 females(35%). Caffeine was given to 24 babies (60%) and aminophylline to 16 babies (40%). There was no significant difference in the drug levels achieved by both the drugs. The overall survival of the infants in the study group was 40%. 15 babies survived while 25 babies died. There was no correlation between the methylxanthines and survival.</p>

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

SANKPAL D M, PRADNYESH GORAD Role of Methylxanthines in The Treatment of Apnea in Neonates / Indian Journal of Applied Research, Vol.5, Issue : 8 August 2015

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