Risk Evaluation of Future Pregnancy among Patients with Recurrent Abortion

Sumitha Prabhu PS; Sheena Joe; Aneesh P; Deepthi T; Chandni Lal; Dinesh Roy D

Volume : VI, Issue : VI, June - 2016

Risk Evaluation of Future Pregnancy among Patients with Recurrent Abortion

Sumitha Prabhu Ps, Sheena Joe, Aneesh P, Deepthi T, Chandni Lal, Dinesh Roy D

Abstract :

 Recurrent pregnancy loss (RPL) is a common occurrence, with approximately 15% of all clinically recognized pregnancies resulting in pregnancy failure. RPL also referred as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period. Based on the incidence of sporadic pregnancy loss, the incidence of recurrent pregnancy loss should be approximately 1 in 300 pregnancies. However, epidemiologic studies have revealed that 1% to 2% of women experience recurrent pregnancy loss. The etiology of recurrent miscarriage includes genetic abnormalities, autoimmune related conditions, structural abnormalities, infections, endocrine disorders, and unknown factors. The present study was carried out in 48 couples suffering with varying degrees of pregnancy loss were selected as study subject. The present study highlights the risk evaluation of future pregnancy among patients with recurrent abortion by cytogenetics. The cytogenetic analysis results were correlated with various demographic and clinical aspects of couples with RPL. Increase in number of gestations, spontaneous abortions and MTPs showed increased incidence of abnormal fetal karyotypes among the study subjects. The results were correlated with various demographic and clinical aspects of infertile couples. Risk factors such as increasing maternal age, increasing paternal age, duration of married life, history of parental infection, etc can lead to fetal loss. Modification of lifestyle, along with preventive measures against teratogenic infection, and awareness of the role of genetics in the etiology of RPL will help in reducing the risk for recurrent pregnancy loss.