Volume : VIII, Issue : XII, December - 2018

Retrospective study of electrolytes change with concomitant usage of SGLT2I and diuretics in T2DM patients

Dr. Sayak Roy

Abstract :

 

Background: SGLT–2Is (sodium glucose co–transporter 2 Inhibitors) group of drugs lead to diuresis and might be associated with the electrolyte loss when used concomitantly with diuretics in T2DM patients (Type 2 Diabetes Mellitus). This was a single center, retrospective, non–interventional real world observational study to evaluate changes in sodium and potassium levels with use of diuretics and SGLT–2Is together.

Methodology: The study was conducted on 62 type 2 diabetics (HbA1C ≥ 6.5) patients (under prevailing international guidelines). All the patients received Empagliflozin (EGF) or Dapagliflozin (DFG) and various diuretics like Chlorthalidone (CTD), hydrochlorothiazide (HTZ), torsemide or eplerenone or combinations of these components (as per labeled indications). Patients with both baseline and post–treatment values of body weight, sodium (Na), potassium (K) and blood pressure were considered for further evaluation. The mean duration of study was 4 weeks. The purpose of study was to find out any change in sodium, potassium levels as well as weight and BP after 4 weeks from baseline.

Results: After a mean study duration of 4 weeks in 62 patients, no significant alterations were observed in Na levels from a baseline level of 138.40 ± 3.62 mmol/L (mean ± SD) to 137.95 ± 3.68 mmol/L after 4 weeks (p=0.238) and K levels from a baseline level of 4.31 ± 0.48 mmol/L (mean ± SD) to 4.28 ± 0.52 mmol/L (p=0.709) after 4 weeks. However, significant reductions were achieved in the body weight and blood pressure.

Conclusions: Concomitant usage of SGLT2I with diuretics in real world setting doesn’t cause sodium and potassium electrolyte abnormalities but there is significant weight loss and BP lowering capacity due to the multiple modes of actions of this molecule. 

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Retrospective study of electrolytes change with concomitant usage of SGLT2I and diuretics in T2DM patients , Dr. Sayak Roy , INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-12 | December-2018

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