Volume : III, Issue : X, October - 2013

Regulatory T Cells in Pediatric Lupus Nephritis

Zahran F. , Al Haggar M. , Derbala S. A.

Abstract :

CD4+ CD25+ regulatory T cells (Tregs) are critical in maintaining self–tolerance and preventing organ–specific autoimmunity. Their role in pediatric lupus nephritis (LN), an autoimmune disease characterized by inappropriate regulation of hyperactivated B and T cells, has not been clearly defined. Using flow cytometry to determine cell populations of CD4+ CD25+ T cells and CD8+CD122+ Tregs in pediatric LN patients and healthy subjects. The frequency of CD4+ CD25+ Tregs was significantly decreased in patients with active LN compared with patients with inactive LN and with controls (3.72% ± 1.43% versus 4.89% ± 1.37% and 9.4% ± 1.17%, respectively; P ≤0.01 and P < 0.001, respectively), The frequency of CD8+CD122+ was significantly decreased in active LN as compared to healthy control group (9.69%±3.9 versus 12.43%±3.87% and 29.81%±5.5; P:<0.01 and ≤0.001 respectively and there was insignificant difference in active LN as compared to inactive LN (9.69%±3.9 versus 12.43%±3.87% , P>0.05). We demonstrated reduced CD4+ CD25+ Treg levels indicating a role of CD4+ Tregs in the pathogenesis of SLE.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Zahran F., Al-haggar M., Derbala S.A. / Regulatory T Cells in Pediatric Lupus Nephritis / Indian Journal of Applied Research, Vol.3, Issue.10 October 2013

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