Volume : VI, Issue : X, October - 2016
RANDOMIZED CONTROLLED TRIAL OF TRANEXAMIC ACID AMONG PARTURIENTS AT INCREASED RISK FOR POSTPARTUM HEMORRHAGE UNDERGOING CESAREAN DELIVERY IN A TERTIARY CARE TEACHING HOSPITAL AT RIMS KADAPA
Dr. T. Lakshmi Suseela, Dr. S. Jaya Jyothi, Dr. P. Rabbani, Dr. Chb. Jhonsi
Abstract :
Objective: To assess the effects of tranexamic acid among patients undergoing cesarean delivery who were at high risk of postpartum hemorrhage for Obstetrics and Gynaecology department in RIMS Kadapa. Methods: Between August 1, 2014, and April 30, 2015, a randomized controlled trial was performed at a tertiary care teaching hospital at kadapa. Women undergoing an elective or emergency cesarean delivery who were at high risk for postpartum hemorrhage were enrolled. They were randomly assigned using sealed, opaque envelopes to receive 10 mg/kg tranexamic acid or normal saline 10 min before skin incision. Anesthesiologists were not masked to group assignment, but patients and obstetricians were. The primary outcome was need for additional uterotonic drugs within 24 h after delivery. Analyses were by intention to treat. Results: Thirty patients were assigned to each group. Additional uterotonic drugs were required in 7 (23%) patients assigned to tranexamic acid and 25 (83%) patients in the control group (P < 0.001). Conclusion: Intravenous tranexamic acid, administered before skin incision, significantly reduced the requirement for additional uterotonics among women at increased risk for postpartum hemorrhage.
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DOI : 10.36106/ijar
Cite This Article:
Dr. T. Lakshmi Suseela, Dr. S. Jaya Jyothi, Dr. P. Rabbani, Dr.Chb. Jhonsi RANDOMIZED CONTROLLED TRIAL OF TRANEXAMIC ACID AMONG PARTURIENTS AT INCREASED RISK FOR POSTPARTUM HEMORRHAGE UNDERGOING CESAREAN DELIVERY IN A TERTIARY CARE TEACHING HOSPITAL AT RIMS KADAPA Indian Journal of Applied Research,Volume : 6 | Issue : 10 | October 2016
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Dr. T. Lakshmi Suseela, Dr. S. Jaya Jyothi, Dr. P. Rabbani, Dr.Chb. Jhonsi RANDOMIZED CONTROLLED TRIAL OF TRANEXAMIC ACID AMONG PARTURIENTS AT INCREASED RISK FOR POSTPARTUM HEMORRHAGE UNDERGOING CESAREAN DELIVERY IN A TERTIARY CARE TEACHING HOSPITAL AT RIMS KADAPA Indian Journal of Applied Research,Volume : 6 | Issue : 10 | October 2016
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